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The fertilization success from the oocyte´s perspective: Open call for Research Topic in Frontiers in Cell and Developmental Biology 2020. Guest Associate Editor: Marcela A. Michaut. Sitio web:

Pleiotropic effects of alpha-SNAP M105I mutation on oocyte biology: ultrastructural and cellular changes that adversely affect female fertility in mice. de Paola M, Miró MP, Ratto M, Bátiz LF, Michaut MA. Scientific Reports. 2019 Nov 22;9(1):17374. 

Live imaging of cortical granule exocytosis reveals that in vitro matured mouse oocytes are not fully competent to secret their content. Cappa AI, de Paola M, Wetten P, De Blas GA, Michaut MA. Biology Open 2018 Dec 3;7(12). DOI: 10.1242/bio.031872. First Author interview en 

Alpha-SNAP is highly expressed in mouse granulosa cells and plays a key role in ovarian follicle development and female fertility. Arcos A, Gianetti D, de Paola MM, Velásquez Z, Acuña D, Miró MP, Toro G, Muñoz RI, Michaut* MA, Bátiz LF* (corresponding authors). Scientific Reports 2017 Sep 18;7(1):11765. 

Rab3A, a possible marker of cortical granules, participates in cortical reaction in mouse eggs. Bello OD, Cappa AI, de Paola MM, Zanetti MN, Fukuda M, Fissore RA, Mayorga LS, Michaut MA. Experimental Cell Research 2016 Sep 10; 347(1): 42–51. 

Cortical Granule Exocytosis is Mediated by alpha-SNAP and N-Ethilmaleimide Sensitive Factor in Mouse Eggs. de Paola MM, Bello OD, Michaut MA. PLos ONE 2015 Aug 12; 10(8): e0135679. 

MARCKS protein is phosphorylated and regulates calcium mobilization during human acrosomal exocytosis. Rodríguez Peña MJ, Castillo Bennett JV, Soler OM, Mayorga LS, Michaut  MA. PLoS ONE 2013 May 21;8(5):e64551. 

RIM, Munc13, and Rab3A interplay in acrosomal exocytosis. Bello OD, Zanetti MN, Mayorga LS, Michaut MA. Experimental Cell Research 2012 Mar 10; 318(5):478-88. Epub 2012 Jan 10. DOI 10.1016/j.yexcr.2012.01.002 

Sperm from hyh mice carrying a point mutation in alphaSNAP have a defect in acrosome reaction. Bátiz LF*, De Blas GA*, Michaut MA*, Ramírez AR, Rodríguez F, Ratto MH, Oliver C, Tomes CN, Rodríguez EM, Mayorga LS (*First authors). PLoS ONE 2009 Mar 23; 4(3): e4963. 

Calmodulin and CaMKII in the sperm principal piece: evidence for a motility-related calcium/calmodulin pathway. Schligmann K, Michaut MA, McElwee JL, Wolff CA, Travis AJ, Turner RM. Journal of Andrology 2007 Sep-Oct; 28(5):706-16. 

Protein kinase C-mediated phosphorylation of the two polybasic regions of Synaptotagmin VI. Roggero CM, Tomes CN, De Blas GA, Castillo J, Michaut MA, Fukuda M, Mayorga LS. Developmental Biology 2005 Sep 15; 285(2):422-35. 

Phosphorylated MARCKS: a novel centrosome component that also defines a peripheral subdomain of the cortical actin cap in mouse eggs. Michaut MA, Williams CJ, Schultz R. Developmental Biology 2005 April 1; 280(1):26-37. 

Alpha-SNAP and NSF are required in a priming step during the human sperm acrosome reaction. Tomes CN, De Blas G, Michaut MA, Farre E, Cherhitin O, Visconti P, Mayorga L. Mol Hum Reprod. 2005 Jan 1, 11(1):43-51. 

The intraacrosomal calcium pool plays a direct role in acrosomal exocytosis. De Blas G, Michaut M, Trevino CL, Tomes CN, Yunes R, Darszon A, Mayorga LS. Journal of Biological Chemistry 2002 Dec 20; 277(51): 4932649331. DOI: 10.1074/jbc.M208587200 

Rab3A and calmodulin regulate acrosomal exocytosis by mechanisms that do not require a direct interaction. Yunes R, Tomes CN, Michaut M, De Blas G, Rodruiguez F, Regazzi R, Mayorga LS. FEBS Letter 2002 Aug 14; 525(1-3): 126-130. 

SNARE complex assembly is required for human sperm acrosome reaction. Tomes C, Michaut MA, Ge Blas G, Visconti P, Matti U, Mayorga LS. Developmental Biology 2002 Mar 15; 243(2): 326-338. 

Synaptotagmin VI participates in the acrosome reaction of human spermatozoa. Michaut M, De Blas G, Tomes CN, Yunes R, Fukuda M, Mayorga LS. Developmental Biology 2001 Jul 15; 235(2): 521-529. 

Calcium-triggered acrosomal exocytosis in human spermatozoa requires the coordinated activation of Rab3A and N-ethylmaleimidesensitive factor. Michaut MA, Tomes CN, De Blas G, Yunes R, Mayorga LS. Proceedings of National Academy of Sciences of U S A 2000 Aug 29; 97(18): 9996-10001. 

Rab3A triggers the acrosome reaction in permeabilized human spermatozoa. Yunes R; Michaut MA; Tomes CN, Mayorga LS. Biology of Reproduction 2000 Apr 1. 62(4): 1084-1089. 

Effects of castration on the content and labelling of lipids in male rat liver. Michaut MA, Carrasco M, Gimenez MS.  Hormone and Metabolic Research  1992; 24(12): 593-594.